Acute Myocardial Infarction/Heart Failure Nonhuman Primates Disease Model

Myocardial infarction is a serious condition resulting from ischemia-induced damage to the heart, which reduces cardiac blood perfusion, causing a reduction in oxygen supply and abnormal myocardial energy metabolism. At Prisys Biotechnologies, we have developed an NHP model of left anterior descending (LAD) ischemia-induced acute myocardial infarction (AMI). The standard study duration for this model is 4 weeks, with further development into heart failure within 6 months.

Clinical endpoints for this model include electrocardiography (ECG), AST/ALT, CK/CK-MB, CtnI, Myoglobin, and LDH. Our model features ischemia-reperfusion, permanent/transient ischemia, human similar coronary artery structure, and the characteristic clinical ECG changes seen in AMI, such as QRS (Q wave) abnormality, ST segment elevation, and T wave inversion. We also assess post-ischemic effects and complications, such as chronic heart diseases, cardio-renal syndrome, and heart failure, to better understand the full spectrum of this condition.

In addition to the clinical endpoints mentioned above, this model can also be used to assess the effectiveness of potential therapeutic interventions for treating AMI and its associated complications. For example, pharmacological agents targeting inflammation, oxidative stress, and cardiac remodeling can be evaluated using this model.

Furthermore, the LAD ischemia induced AMI model developed by Prisys Biotechnologies has the advantage of having a similar coronary artery structure to humans, which enhances the translatability of preclinical findings to clinical applications. The model also allows for the investigation of both permanent and transient ischemia, providing a comprehensive understanding of the pathophysiology of AMI.

In summary, the LAD ischemia induced AMI model developed by Prisys Biotechnologies is a valuable tool for studying the mechanisms underlying myocardial infarction and its associated complications, as well as for evaluating potential therapeutic interventions.
 

Populární Tagy: acute myocardial infarction/heart failure nonhuman primates disease model, China, research, study, monkey, gene therapy